Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GPR39 | O43194 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20777354 | 0.90 | NOS2 (0.44) | NOS2HDAC8HDAC6NPC1RAB9A | |
| SCHEMBL526424 | 0.87 | NOS2 (0.55) | NOS2HDAC8HDAC6NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL1919379 | 0.85 | NOS2 (0.54) | NOS2HDAC8HDAC6NPC1RAB9A | |
| SCHEMBL16548498 | 0.83 | ALDH1A1 (0.58) | NOS2NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7919601 | 0.83 | ALDH1A1 (0.54) | NOS2HDAC8HDAC6NPC1RAB9A | |
| SCHEMBL1579641 | 0.81 | KDM4E (0.60) | NOS2SMN1; SMN2ALDH1A1MAPTGPR39 | |
| SCHEMBL29211498 | 0.80 | KDM4E (0.58) | NOS2SMN1; SMN2ALDH1A1MAPTGPR39 | |
| SCHEMBL25091032 | 0.79 | NOS2 (0.52) | NOS2HDAC8HDAC6NPC1RAB9A | |
| SCHEMBL3235320 | 0.79 | MAPK1 (0.62) | NOS2NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17730328 | 0.79 | MERTK (0.55) | NOS2HDAC8HDAC6NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010030360-A1 | 3H-IMIDAZO[4,5-b]PYRIDIN-5-OL DERIVATIVES USEFUL IN THE TREATMENT OF GPR81 RECEPTOR DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2010-03-18 | — | — | WO | disclosed |