Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 7/20 | 0.42 |
| ▸ | BTK | Q06187 | 10/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265213 | 0.92 | DPP4 (0.42) | LCKJAK3DPP4BTKKMT2A | |
| SCHEMBL3263178 | 0.87 | BTK (0.45) | LCKJAK3EGFRDPP4BTK | |
| SCHEMBL3260799 | 0.85 | BTK (0.47) | DPP4BTK | |
| SCHEMBL3263368 | 0.85 | DPP4 (0.40) | DPP4BTK | |
| SCHEMBL3263367 | 0.85 | DPP4 (0.40) | DPP4BTK | |
| SCHEMBL2491482 | 0.81 | BTK (0.58) | LCKJAK3EGFRBTKKMT2A | |
| SCHEMBL9984843 | 0.81 | BTK (0.47) | LCKJAK3EGFRBTKKMT2A | |
| SCHEMBL2490655 | 0.79 | BTK (0.47) | LCKJAK3EGFRBTKKMT2A | |
| SCHEMBL2492299 | 0.79 | BTK (0.47) | LCKJAK3EGFRBTKKMT2A | |
| SCHEMBL13303594 | 0.76 | BTK (0.46) | LCKJAK3EGFRBTKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068806-A1 | AMIDE DERIVATIVES AS BTK INHIBITORS IN THE TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFLAMMATORY DISORDERS AS WELL AS CANCER | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | claimed |
| WO-2010068806-A1 | AMIDE DERIVATIVES AS BTK INHIBITORS IN THE TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFLAMMATORY DISORDERS AS WELL AS CANCER | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | disclosed |