Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 11/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 7/20 | 0.35 |
| ▸ | FGR | P09769 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | TEC | P42680 | 1/20 | 0.35 |
| ▸ | BMX | P51813 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263367 | 1.00 | DPP4 (0.40) | DPP4PDE2APDE3BNPC1PRNP | |
| SCHEMBL3260799 | 0.89 | BTK (0.47) | DPP4BTKFGRSRCTEC | |
| SCHEMBL3263477 | 0.85 | LCK (0.45) | DPP4BTK | |
| SCHEMBL3265213 | 0.83 | DPP4 (0.42) | DPP4BTK | |
| SCHEMBL3263178 | 0.82 | BTK (0.45) | DPP4BTK | |
| SCHEMBL2493910 | 0.81 | RAB9A (0.40) | NPC1PRNPRAB9ABTKFGR | |
| SCHEMBL3262413 | 0.80 | SYK (0.47) | NPC1PRNPRAB9ABTKFGR | |
| SCHEMBL3262416 | 0.80 | SYK (0.47) | NPC1PRNPRAB9ABTKFGR | |
| SCHEMBL3266238 | 0.79 | DPP4 (0.40) | DPP4PDE2APDE3BNPC1PRNP | |
| SCHEMBL3266237 | 0.79 | DPP4 (0.40) | DPP4PDE2APDE3BNPC1PRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068806-A1 | AMIDE DERIVATIVES AS BTK INHIBITORS IN THE TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFLAMMATORY DISORDERS AS WELL AS CANCER | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | claimed |