Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 15/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263477 | 0.87 | LCK (0.45) | BTKDPP4LCKJAK3EGFR | |
| SCHEMBL3260799 | 0.84 | BTK (0.47) | BTKDPP4 | |
| SCHEMBL3265213 | 0.83 | DPP4 (0.42) | BTKDPP4LCKJAK3KMT2A | |
| SCHEMBL3263367 | 0.82 | DPP4 (0.40) | BTKDPP4 | |
| SCHEMBL3263368 | 0.82 | DPP4 (0.40) | BTKDPP4 | |
| SCHEMBL9985224 | 0.81 | BTK (0.49) | BTKLCKJAK3EGFRKMT2A | |
| SCHEMBL13303602 | 0.76 | DPP4 (0.48) | DPP4 | |
| SCHEMBL3263746 | 0.73 | LCK (0.40) | BTKLCKJAK3EGFRKMT2A | |
| SCHEMBL3263743 | 0.73 | LCK (0.40) | BTKLCKJAK3EGFRKMT2A | |
| SCHEMBL3262494 | 0.71 | BTK (0.46) | BTKDPP4LCKJAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068806-A1 | AMIDE DERIVATIVES AS BTK INHIBITORS IN THE TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFLAMMATORY DISORDERS AS WELL AS CANCER | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | claimed |
| WO-2010068806-A1 | AMIDE DERIVATIVES AS BTK INHIBITORS IN THE TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFLAMMATORY DISORDERS AS WELL AS CANCER | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | disclosed |