Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.47 |
| ▸ | FGR | P09769 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | TEC | P42680 | 1/20 | 0.46 |
| ▸ | BMX | P51813 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 9/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263368 | 0.89 | DPP4 (0.40) | BTKFGRSRCTECBMX | |
| SCHEMBL3263367 | 0.89 | DPP4 (0.40) | BTKFGRSRCTECBMX | |
| SCHEMBL3268115 | 0.87 | BTK (0.45) | BTKDPP4CHRNA7HTR3EHTR3B | |
| SCHEMBL3268106 | 0.87 | BTK (0.45) | BTKDPP4CHRNA7HTR3EHTR3B | |
| SCHEMBL3263477 | 0.85 | LCK (0.45) | BTKDPP4 | |
| SCHEMBL3262494 | 0.84 | BTK (0.46) | BTKDPP4CHRNA7HTR3A | |
| SCHEMBL3265213 | 0.84 | DPP4 (0.42) | BTKDPP4 | |
| SCHEMBL3263178 | 0.84 | BTK (0.45) | BTKDPP4 | |
| SCHEMBL2491729 | 0.83 | BTK (0.51) | BTKFGRSRCTECBMX | |
| SCHEMBL13303602 | 0.76 | DPP4 (0.48) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068806-A1 | AMIDE DERIVATIVES AS BTK INHIBITORS IN THE TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFLAMMATORY DISORDERS AS WELL AS CANCER | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | claimed |
| WO-2010068806-A1 | AMIDE DERIVATIVES AS BTK INHIBITORS IN THE TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFLAMMATORY DISORDERS AS WELL AS CANCER | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | disclosed |