Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL8054908 | 0.94 | ALDH1A1 (0.52) | ALDH1A1HSD17B10HIF1ACYP1B1KDM4E | |
| Benzene SCHEMBL28556778 | 0.92 | ALDH1A1 (0.50) | ALDH1A1HSD17B10HIF1ACYP1B1KDM4E | |
| Phosphoric Acid SCHEMBL3264407 | 0.92 | ALDH1A1 (0.50) | ALDH1A1HSD17B10HIF1ACYP1B1KDM4E | |
| Cyclohexane SCHEMBL27849973 | 0.85 | ALDH1A1 (0.62) | ALDH1A1HSD17B10HIF1ACYP1B1KDM4E | |
| Phosphoric Acid SCHEMBL28139728 | 0.80 | ALDH1A1 (0.41) | ALDH1A1HSD17B10HIF1ACYP1B1KDM4E | |
| SCHEMBL4850502 | 0.80 | ALDH1A1 (0.68) | ALDH1A1HSD17B10HIF1ACYP1B1KDM4E | |
| SCHEMBL15063036 | 0.80 | ALDH1A1 (0.68) | ALDH1A1HSD17B10HIF1ACYP1B1KDM4E | |
| SCHEMBL31127473 | 0.80 | ALDH1A1 (0.68) | ALDH1A1HSD17B10HIF1ACYP1B1KDM4E | |
| SCHEMBL25966 | 0.80 | ALDH1A1 (0.68) | ALDH1A1HSD17B10HIF1ACYP1B1KDM4E | |
| SCHEMBL29975167 | 0.80 | ALDH1A1 (0.68) | ALDH1A1HSD17B10HIF1ACYP1B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745108-B2 | Method for identifying terpene synthase | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-06-29 | — | — | US | claimed |
| US-20070264632-A1 | Method for Identification of Enzymes | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2007-11-15 | — | — | US | claimed |
| WO-2005057176-A2 | METHOD FOR IDENTIFICATION OF ENZYMES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-06-23 | — | — | WO | claimed |
| US-7745108-B2 | Method for identifying terpene synthase | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-06-29 | — | — | US | disclosed |
| US-20070264632-A1 | Method for Identification of Enzymes | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2007-11-15 | — | — | US | disclosed |
| WO-2005057176-A2 | METHOD FOR IDENTIFICATION OF ENZYMES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-06-23 | — | — | WO | disclosed |