Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238619 | 0.85 | KDM4E (0.34) | ALDH1A1HDAC1KDM4E | |
| SCHEMBL3233610 | 0.80 | KDM4E (0.38) | MAPTALDH1A1HDAC1KDM4E | |
| SCHEMBL3227664 | 0.79 | HDAC1 (0.32) | HDAC1 | |
| SCHEMBL3240737 | 0.79 | MAPK14 (0.48) | ENPP2MAPTALDH1A1L3MBTL1HDAC1 | |
| SCHEMBL3235671 | 0.77 | GRM1 (0.44) | MAPTPOLBHDAC1SMN1; SMN2 | |
| SCHEMBL3262051 | 0.76 | CYP1A2 (0.43) | ENPP2MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL3241080 | 0.75 | MPO (0.40) | MAPTHDAC1 | |
| SCHEMBL3230365 | 0.74 | HDAC1 (0.43) | ALDH1A1L3MBTL1HDAC1SMN1; SMN2 | |
| SCHEMBL3236826 | 0.73 | KDM4E (0.38) | MAPTALDH1A1HDAC1KDM4E | |
| SCHEMBL3262614 | 0.71 | HDAC3 (0.50) | HDAC1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |