Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ATP4A | P20648 | 2/20 | 0.40 |
| ▸ | ATP4B | P51164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235671 | 0.94 | GRM1 (0.44) | MAPK14HDAC1HDAC6HDAC9KMT2A | |
| SCHEMBL3262051 | 0.88 | CYP1A2 (0.43) | MAPK14KMT2AMEN1MAPTLMNA | |
| SCHEMBL3233610 | 0.86 | KDM4E (0.38) | MAPK14HDAC1MAPTLMNARAB9A | |
| SCHEMBL3238619 | 0.85 | KDM4E (0.34) | MAPK14HDAC1HDAC6HDAC9LMNA | |
| SCHEMBL3233744 | 0.84 | KMT2A (0.47) | MAPK14HDAC1HDAC6HDAC9KMT2A | |
| SCHEMBL3227664 | 0.84 | HDAC1 (0.32) | MAPK14HDAC1 | |
| SCHEMBL3234299 | 0.81 | RAB9A (0.48) | HDAC1HDAC6HDAC9KMT2AMEN1 | |
| SCHEMBL3241080 | 0.80 | MPO (0.40) | HDAC1MAPTMAPK1GAA | |
| SCHEMBL3262923 | 0.80 | GRM1 (0.44) | MAPK14HDAC1HDAC6HDAC9KMT2A | |
| SCHEMBL3230365 | 0.79 | HDAC1 (0.43) | HDAC1KMT2AMEN1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |