Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.30 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3233610 | 0.86 | KDM4E (0.38) | HDAC1HDAC3MAPK14PTGDR2 | |
| SCHEMBL3238619 | 0.85 | KDM4E (0.34) | HDAC1HDAC3MAPK14MPO | |
| SCHEMBL3240737 | 0.84 | MAPK14 (0.48) | HDAC1MAPK14 | |
| SCHEMBL3235671 | 0.82 | GRM1 (0.44) | HDAC1MAPK14 | |
| SCHEMBL3241080 | 0.80 | MPO (0.40) | HDAC1HDAC3MPO | |
| SCHEMBL3230345 | 0.80 | MLYCD (0.35) | HDAC1HDAC3GPBAR1MPO | |
| SCHEMBL3230365 | 0.79 | HDAC1 (0.43) | HDAC1HDAC3MPO | |
| SCHEMBL3263757 | 0.79 | ENPP2 (0.33) | HDAC1 | |
| SCHEMBL3236826 | 0.78 | KDM4E (0.38) | HDAC1HDAC3MAPK14PTGDR2 | |
| SCHEMBL3236799 | 0.76 | LMNA (0.44) | HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |