Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | QDPR | P09417 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL770764 | 0.86 | SMN1; SMN2 (0.33) | ALDH1A1 | |
| SCHEMBL2824470 | 0.84 | ALDH1A1 (0.33) | LMNAALDH1A1HPGDHIF1AHSD11B1 | |
| SCHEMBL769747 | 0.83 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL771484 | 0.81 | LMNA (0.30) | LMNA | |
| SCHEMBL771465 | 0.81 | LMNA (0.41) | LMNAHPGD | |
| SCHEMBL770161 | 0.79 | DPP4 (0.37) | — | |
| SCHEMBL3242488 | 0.79 | HPGD (0.31) | ALDH1A1HPGD | |
| SCHEMBL770945 | 0.79 | NAAA (0.36) | LMNA | |
| SCHEMBL770257 | 0.79 | ALDH1A1 (0.37) | LMNAALDH1A1 | |
| SCHEMBL770545 | 0.78 | RBP4 (0.35) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078001-B1 | DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11 -HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-05-12 | — | — | EP | claimed |