Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.63 |
| ▸ | RAB9A | P51151 | 8/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15551680 | 0.85 | CA1 (0.59) | NPC1RAB9ASMN1; SMN2HPGDCA1 | |
| SCHEMBL16468330 | 0.84 | HIF1A (0.48) | NPC1CA1CA2CA9MTNR1A | |
| SCHEMBL15550535 | 0.83 | ALDH1A1 (0.66) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL11424416 | 0.82 | NPC1 (0.93) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL16899331 | 0.81 | CA1 (0.71) | NPC1RAB9ASMN1; SMN2CA1CA2 | |
| SCHEMBL22816055 | 0.81 | MTNR1A (0.58) | NPC1CA1CA2CA9LMNA | |
| SCHEMBL16758328 | 0.81 | CA2 (0.55) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL18222600 | 0.81 | CA1 (0.57) | NPC1HPGDCA1CA2CA9 | |
| SCHEMBL1561011 | 0.80 | HIF1A (0.47) | NPC1HPGDRECQLCA1CA2 | |
| SCHEMBL22108450 | 0.80 | CA2 (0.52) | NPC1RAB9ASMN1; SMN2HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |