Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27495645 | 0.84 | CHRM4 (0.43) | ALDH1A1CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL7744409 | 0.71 | ALDH1A1 (0.41) | TDP1L3MBTL1ALDH1A1NPC1HPGD | |
| SCHEMBL3252229 | 0.70 | GRM4 (0.34) | TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL14895764 | 0.69 | TDP1 (0.42) | TDP1L3MBTL1 | |
| SCHEMBL15322628 | 0.67 | GPR84 (0.56) | TDP1L3MBTL1GPR84 | |
| SCHEMBL2876088 | 0.67 | MEN1 (0.45) | ALDH1A1NPC1HPGDKMT2AMEN1 | |
| SCHEMBL28378989 | 0.66 | PARP1 (0.43) | ALDH1A1HPGDHTT | |
| SCHEMBL29117330 | 0.66 | MEN1 (0.47) | ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL30327261 | 0.65 | HTR2C (0.43) | TDP1L3MBTL1NPC1CHRM4CHRM5 | |
| SCHEMBL13165350 | 0.63 | CHRM4 (0.42) | TDP1L3MBTL1ALDH1A1NPC1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1475094-B1 | Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use | USTAV EX BOTAN AKADEMIE VED CE (CZ) | 2010-07-28 | — | — | EP | disclosed |
| US-20070167466-A1 | \"Pyrazolo [4,3-d]pyrimidines, processes for their preparation and methods of use\ | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2007-07-19 | — | — | US | disclosed |
| WO-2004098608-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS OF USE | ÚSTAV EXPERIMENTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY (CZ) | 2004-11-18 | — | — | WO | disclosed |
| EP-1475094-A1 | Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use | Ustav Experimentalni Botaniky Akademie ved Ceské Republiky (CZ) | 2004-11-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167466-A1 | \"Pyrazolo [4,3-d]pyrimidines, processes for their preparation and methods of use\ | CBR3, PYM1, PNPO | TDP1 2938/4885L3MBTL1 4294/4885ALDH1A1 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.