Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 7/20 | 0.60 |
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | CDC42 | P60953 | 3/20 | 0.47 |
| ▸ | RAC1 | P63000 | 3/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketoprofen SCHEMBL7991457 | 0.83 | PTGS2 (0.69) | PTGS2LMNAMAPK1ABCC4HTT | |
| Ketorolac SCHEMBL258489 | 0.78 | PTGS2 (0.66) | PTGS2LMNAMAPK1ABCC4HTT | |
| Ketorolac SCHEMBL6378057 | 0.78 | PTGS2 (1.00) | PTGS2LMNAMAPK1ABCC4HTT | |
| Ketorolac SCHEMBL977126 | 0.78 | PTGS2 (1.00) | PTGS2LMNAMAPK1ABCC4HTT | |
| Ketoprofen SCHEMBL5816775 | 0.78 | PTGS2 (0.67) | PTGS2LMNAMAPK1HTTCYP1A2 | |
| Ketorolac SCHEMBL5036 | 0.78 | PTGS2 (1.00) | PTGS2LMNAMAPK1ABCC4HTT | |
| Ketorolac SCHEMBL7889476 | 0.77 | PTGS2 (0.98) | PTGS2LMNAMAPK1ABCC4HTT | |
| Ketoprofen SCHEMBL8759161 | 0.73 | PTGS1 (0.76) | PTGS2LMNAMAPK1HTTCYP1A2 | |
| Ketoprofen SCHEMBL31529697 | 0.73 | PTGS1 (0.76) | PTGS2LMNAMAPK1HTTCYP1A2 | |
| Dexketoprofen SCHEMBL1065399 | 0.73 | PTGS1 (0.76) | PTGS2LMNAMAPK1HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010006046-A1 | NSAID DELIVERY FROM POLYARYLATES | TYRX PHARMA, INC. (US) | 2010-01-14 | — | — | WO | disclosed |