Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 10/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264785 | 1.00 | UCHL1 (0.43) | UCHL1AGTR2MCL1CCKBRGRIN1 | |
| SCHEMBL5150050 | 0.89 | CCKBR (0.47) | UCHL1MCL1CCKBRGRIN1GRIN2B | |
| SCHEMBL3188809 | 0.89 | NR1H2 (0.43) | UCHL1MCL1GRIN1GRIN2BHTRA1 | |
| SCHEMBL13481242 | 0.89 | NR1H2 (0.43) | UCHL1MCL1GRIN1GRIN2BHTRA1 | |
| SCHEMBL8339060 | 0.89 | NR1H2 (0.43) | UCHL1MCL1GRIN1GRIN2BHTRA1 | |
| SCHEMBL24739556 | 0.89 | NR1H2 (0.43) | UCHL1MCL1GRIN1GRIN2BHTRA1 | |
| SCHEMBL16369937 | 0.86 | MCL1 (0.43) | UCHL1MCL1HTRA1 | |
| SCHEMBL16370639 | 0.86 | MCL1 (0.43) | UCHL1MCL1HTRA1 | |
| SCHEMBL16369939 | 0.86 | MCL1 (0.43) | UCHL1MCL1HTRA1 | |
| SCHEMBL28722395 | 0.85 | GPR119 (0.42) | UCHL1MCL1CCKBRGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659305-B2 | 4-carbo- or heterocyclic alkyl-, oxy-, amino-, and thio-substituted; e.g., 2S, 4S)-4-(3-Chloro-phenoxy)-pyrrolidine-2-carboxylic acid; controlling neurotransmitter release; uses include general treatment of pain, particularly neuropathic pain. | PFIZER INC. (US) | 2010-02-09 | — | — | US | disclosed |