Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 10/20 | 0.47 |
| ▸ | MET | P08581 | 6/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264905 | 0.87 | INSR (0.46) | INSRMETALKIKBKBGSK3B | |
| SCHEMBL3264899 | 0.83 | INSR (0.58) | INSRMETALKGSK3BDYRK1A | |
| SCHEMBL3005454 | 0.74 | MET (0.61) | INSRMETALKEGFR | |
| SCHEMBL3006537 | 0.72 | MET (0.51) | INSRMETALKJAK2 | |
| SCHEMBL2991920 | 0.71 | MET (0.49) | INSRMETALKJAK2 | |
| SCHEMBL2938646 | 0.70 | INSR (0.77) | INSRMETALK | |
| SCHEMBL886685 | 0.70 | INSR (0.77) | INSRMETALK | |
| SCHEMBL886373 | 0.70 | INSR (0.86) | INSRMETALK | |
| SCHEMBL18832751 | 0.67 | INSR (0.77) | INSRMETALKEGFR | |
| SCHEMBL3006532 | 0.66 | INSR (0.40) | INSRMETALKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |