Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | MEN1 | O00255 | 3/20 | 0.75 |
| ▸ | GAA | P10253 | 2/20 | 0.75 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | RPA1 | P27694 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291031 | 0.86 | MAPT (1.00) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL3636076 | 0.85 | KDM4E (0.55) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL3382868 | 0.85 | KDM4E (0.55) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL3383227 | 0.85 | MAPT (0.55) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL3382448 | 0.81 | SMN1; SMN2 (0.64) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL20120113 | 0.80 | KDM4E (0.73) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL4744827 | 0.78 | CYP1A2 (0.73) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL3382621 | 0.78 | ALDH1A1 (0.73) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL30254999 | 0.78 | ALDH1A1 (0.73) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL19871249 | 0.77 | MAPT (0.63) | MAPTKMT2AKDM4EMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010012397-A1 | N-(INDOL-3-YLALKYL)(HETERO)ARYLAMIDE DERIVATIVES AS MODULATORS OF THE EP2 RECEPTOR | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-02-04 | — | — | WO | claimed |
| EP-2149551-A1 | N-(indol-3-ylalkyl)-(hetero)arylamid derivatives as modulators of EP2 receptors | Bayer Schering Pharma AG (DE) | 2010-02-03 | — | — | EP | claimed |