Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | SHBG | P04278 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.46 |
| ▸ | FOS | P01100 | 2/20 | 0.46 |
| ▸ | TTR | P02766 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234487 | 0.91 | ESR1 (0.45) | ESR1ESR2SHBGALOX15ALOX12 | |
| SCHEMBL3237259 | 0.91 | ESR1 (0.47) | ESR1ESR2SHBGALOX15ALOX12 | |
| SCHEMBL3234340 | 0.90 | ESR1 (0.66) | ESR1ESR2SHBGALOX15ALOX12 | |
| SCHEMBL3232262 | 0.90 | ESR1 (0.66) | ESR1ESR2SHBGALDH1A1CYP3A4 | |
| SCHEMBL8251707 | 0.82 | GABRA1 (0.63) | ESR1SHBGALOX15ALOX12ALDH1A1 | |
| SCHEMBL9908608 | 0.80 | SHBG (0.64) | SHBGALOX15ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10070163 | 0.80 | ALOX15 (0.66) | ESR1ESR2ALOX15ALOX12ALDH1A1 | |
| SCHEMBL14478217 | 0.79 | TAAR1 (0.55) | ESR1ALOX15ALOX12ALDH1A1HPGD | |
| Bromide SCHEMBL9513709 | 0.77 | SHBG (0.51) | SHBGALOX15ALOX12ALDH1A1HPGD | |
| SCHEMBL11223229 | 0.77 | SHBG (0.47) | ESR1SHBGALOX15ALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010030787-A1 | ESTROGEN RECEPTOR LIGANDS | RADIUS HEALTH, INC. (US) | 2010-03-18 | — | — | WO | claimed |
| WO-2010030787-A1 | ESTROGEN RECEPTOR LIGANDS | RADIUS HEALTH, INC. (US) | 2010-03-18 | — | — | WO | disclosed |
| WO-2010030787-A1 | ESTROGEN RECEPTOR LIGANDS | RADIUS HEALTH, INC. (US) | 2010-03-18 | — | — | WO | disclosed |