Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | HTT | P42858 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28808612 | 0.84 | CA9 (0.62) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL23057256 | 0.81 | LMNA (0.73) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10592845 | 0.81 | LMNA (0.73) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5023540 | 0.81 | HTT (0.73) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5024746 | 0.79 | LMNA (0.70) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4069104 | 0.79 | LMNA (0.70) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3314209 | 0.79 | LMNA (0.70) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL196165 | 0.79 | HTT (0.53) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2932439 | 0.79 | LMNA (0.70) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL23043651 | 0.79 | LMNA (0.70) | LMNAHTTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109232330-B | Method for synthesizing benzene sulfonamide compound from benzene sulfonyl chloride compound and triethylamine through metal-free catalysis | 中国人民解放军国防科技大学 | 2021-03-26 | — | — | CN | disclosed |
| WO-2021041866-A1 | SMALL MOLECULE AGONISTS OF MUCOLIPIN 1 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-03-04 | — | — | WO | disclosed |
| EP-2133340-B1 | Novel benzazepine derivatives | GLAXO GROUP LTD (GB) | 2013-01-16 | — | — | EP | disclosed |
| EP-2186516-B1 | Novel benzazepine derivative | GLAXO GROUP LTD (GB) | 2013-01-16 | — | — | EP | disclosed |
| EP-2186516-A1 | Novel benzazepine derivative | Glaxo Group Limited (GB) | 2010-05-19 | — | — | EP | disclosed |
| EP-2133340-A1 | Novel benzazepine derivatives | Glaxo Group Limited (GB) | 2009-12-16 | — | — | EP | disclosed |
| EP-1572215-B1 | BENZO[D]AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LTD (GB) | 2009-09-02 | — | — | EP | disclosed |
| CN-1905872-A | Amino substituted pyridinyl methanone compounds useful in treating kinase disorders | JANSSEN PHARMACEUTICA NV (BE) | 2007-01-31 | — | — | CN | disclosed |
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5693639-A | TREATING URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1997-12-02 | — | — | US | disclosed |
| US-5510386-A | ADMINISTERING TO RELAX SMOOTH MUSCLE OF THE BLADDER | ZENECA LIMITED (GB) | 1996-04-23 | — | — | US | disclosed |
| EP-0625516-A1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | disclosed |