Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | HTT | P42858 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081266 | 0.84 | CA9 (0.62) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL23057256 | 0.81 | LMNA (0.73) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10592845 | 0.81 | LMNA (0.73) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5023540 | 0.81 | HTT (0.73) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3265384 | 0.79 | LMNA (0.70) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2932439 | 0.79 | LMNA (0.70) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL23043651 | 0.79 | LMNA (0.70) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5024746 | 0.79 | LMNA (0.70) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3314209 | 0.79 | LMNA (0.70) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL810965 | 0.79 | LMNA (0.70) | LMNAHTTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117577-A1 | G PROTEIN-COUPLED RECEPTOR AND MODULATORS THEREOF FOR THE TREATMENT OF GABA-RELATED NEUROLOGICAL DISORDERS INCLUDING SLEEP-RELATED DISORDERS | Arena Pharmaceuticals, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008085888-A1 | G PROTEIN-COUPLED RECEPTOR AND MODULATORS THEREOF FOR THE TREATMENT OF GABA-RELATED NEUROLOGICAL DISORDERS INCLUDING SLEEP-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2008-07-17 | — | — | WO | disclosed |