Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.54 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | NEK1 | Q96PY6 | 3/20 | 0.42 |
| ▸ | CIT | O14578 | 3/20 | 0.42 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13457234 | 0.90 | ROCK2 (0.53) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL13457055 | 0.84 | TNIK (0.45) | ROCK2ROCK1CDC42BPAMAPK10NEK1 | |
| SCHEMBL3265228 | 0.84 | ROCK2 (0.58) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL3265194 | 0.82 | ROCK2 (0.78) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL3251718 | 0.81 | CIT (0.55) | ROCK2ROCK1CDC42BPANEK1CIT | |
| SCHEMBL3241319 | 0.81 | ROCK2 (0.56) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL3264837 | 0.81 | ROCK2 (0.56) | ROCK2ROCK1CDC42BPAMAPK10 | |
| SCHEMBL3261889 | 0.74 | ROCK2 (0.71) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL13457117 | 0.74 | RPS6KB1 (0.37) | ROCK2ROCK1CDC42BPAMAPK10CIT | |
| SCHEMBL3262928 | 0.74 | ROCK2 (0.68) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |