Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1871691 | 0.87 | CCR5 (0.39) | CCR5SLC6A2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL12883631 | 0.86 | CHRM1 (0.35) | CCR5HSD11B1TRPV4SLC6A2SLC6A4 | |
| SCHEMBL4163172 | 0.84 | CCR5 (0.40) | CCR5BCHEHSD11B1GPR119CHRM1 | |
| SCHEMBL4163176 | 0.84 | CCR5 (0.40) | CCR5BCHEHSD11B1GPR119CHRM1 | |
| SCHEMBL3265703 | 0.83 | KCNH2 (0.38) | CCR5BCHESLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31702033 | 0.82 | HSD11B1 (0.44) | HSD11B1TRPV4CHRM1CHRM2CHRM3 | |
| SCHEMBL3824368 | 0.80 | CCR5 (0.42) | CCR5HSD11B1GPR119 | |
| SCHEMBL2555618 | 0.79 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL4853479 | 0.79 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL20905448 | 0.79 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010025073-A1 | DIHYDROIMIDAZO [ 1, 5-F] PTERIDINES AS POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-04 | — | — | WO | disclosed |