Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | HRH1 | P35367 | 1/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265484 | 0.81 | HTR2A (0.60) | DRD3HTR2AHTR1ADRD2SLC6A4 | |
| SCHEMBL1039928 | 0.80 | DRD3 (1.00) | DRD3HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL2214899 | 0.78 | HTR2A (0.70) | DRD3HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL3268873 | 0.77 | DRD2 (0.55) | DRD3HTR2AHTR1ADRD2HTR2C | |
| SCHEMBL2213700 | 0.77 | HTR2A (0.74) | DRD3HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL2213871 | 0.77 | HTR2A (0.66) | DRD3HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL2214238 | 0.76 | HTR2A (0.65) | DRD3HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL4519092 | 0.74 | DRD3 (1.00) | DRD3HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL13398528 | 0.74 | HTR2A (0.54) | DRD3HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL13399005 | 0.73 | DRD3 (0.51) | DRD3HTR2AHTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038948-A2 | ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS | GREEN CROSS CORPORATION (KR) | 2010-04-08 | — | — | WO | disclosed |