Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 12/20 | 1.00 |
| ▸ | HTR1A | P08908 | 6/20 | 1.00 |
| ▸ | HTR2A | P28223 | 5/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 6/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432969 | 0.87 | DRD3 (1.00) | DRD3HTR1AHTR2AADRA1AADRA2A | |
| SCHEMBL1077884 | 0.83 | DRD3 (0.71) | DRD3HTR1AHTR2AADRA1AADRA2A | |
| SCHEMBL13382896 | 0.82 | DRD3 (0.69) | DRD3HTR1AHTR2AADRA1AADRA2A | |
| SCHEMBL4519092 | 0.82 | DRD3 (1.00) | DRD3HTR1AHTR2AADRA1AADRA2A | |
| SCHEMBL31061220 | 0.81 | DRD3 (0.84) | DRD3HTR1AHTR2ADRD2HTR2C | |
| SCHEMBL3265653 | 0.80 | DRD3 (0.67) | DRD3HTR1AHTR2AADRA1AADRA2A | |
| SCHEMBL1039929 | 0.80 | DRD3 (0.67) | DRD3HTR1AHTR2AADRA1AADRA2A | |
| SCHEMBL4533987 | 0.80 | SLC6A4 (0.72) | DRD3HTR1AHTR2AADRA1AADRA2A | |
| SCHEMBL4527831 | 0.79 | DRD3 (1.00) | DRD3HTR1AHTR2AADRA1AADRA2A | |
| SCHEMBL4523269 | 0.79 | HTR1A (1.00) | DRD3HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081907-B1 | ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | UNIV SIENA (IT) | 2011-01-26 | — | — | EP | claimed |
| US-20100087445-A1 | ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2010-04-08 | — | — | US | claimed |
| EP-2081907-B1 | ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | UNIV SIENA (IT) | 2011-01-26 | — | — | EP | disclosed |
| EP-2081907-B1 | ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | UNIV SIENA (IT) | 2011-01-26 | — | — | EP | disclosed |
| US-20100087445-A1 | ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2010-04-08 | — | — | US | disclosed |
| US-20100087445-A1 | ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2010-04-08 | — | — | US | disclosed |
| US-20100087445-A1 | ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087445-A1 | ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | HTR2A, HTR3A, HTR2C | DRD3 14/4885HTR1A 4/4885HTR2A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.