Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | ACHE | P22303 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5064660 | 0.91 | ACHE (0.77) | SMN1; SMN2MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL5060999 | 0.89 | SMN1; SMN2 (0.77) | SMN1; SMN2MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL5063966 | 0.86 | ALDH1A1 (0.67) | SMN1; SMN2MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL5065732 | 0.85 | GHSR (0.75) | SMN1; SMN2LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL5060092 | 0.83 | ALDH1A1 (0.67) | SMN1; SMN2MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL5061043 | 0.83 | KMT2A (0.79) | SMN1; SMN2MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL5055810 | 0.83 | ALDH1A1 (0.67) | SMN1; SMN2MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL5059678 | 0.83 | ALDH1A1 (0.61) | SMN1; SMN2MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL5064710 | 0.82 | GPR183 (0.62) | SMN1; SMN2MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL5061523 | 0.82 | ALDH1A1 (0.64) | SMN1; SMN2MAPTKDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | SMN1; SMN2 4546/4885MAPT 4877/4885KDM4E 4565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.