SCHEMBL32659858

SCHEMBL32659858

C[Si](C)(C)CCOCn1c(=O)n(COCC[Si](C)(C)C)c2nc3cc(Cl)c(Br)cc3cc21

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.35
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32659885 0.81 NPC1 (0.32) NPC1
SCHEMBL32659833 0.78 NPC1 (0.45) NPC1MAPT
SCHEMBL32659805 0.77 NPC1 (0.38) NPC1MAPT
SCHEMBL32659868 0.74 NPC1 (0.38) NPC1MAPT
SCHEMBL32659878 0.74 DGAT1 (0.42) NPC1MAPT
SCHEMBL32659847 0.74 DGAT1 (0.35) NPC1MAPT
SCHEMBL31748672 0.73 NPC1 (0.33) NPC1MAPT
SCHEMBL31047151 0.72 NPC1 (0.32) NPC1MAPT
SCHEMBL31202659 0.71 CYP1A2 (0.35) NPC1MAPT
SCHEMBL24607455 0.70 NPC1 (0.35) NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4678641-A1 QUINOLINONE COMPOUND AND NAPHTHYRIDINONE COMPOUND AND USE THEREOF Shanghai Helioson Pharmaceutical Co., Ltd. (CN) 2026-01-14 EP disclosed