Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7690959 | 1.00 | TACR3 (1.00) | TACR3 | |
| SCHEMBL1393945 | 0.85 | TACR3 (1.00) | TACR3 | |
| SCHEMBL7687583 | 0.85 | TACR3 (1.00) | TACR3 | |
| SCHEMBL6837195 | 0.83 | TACR3 (0.83) | TACR3 | |
| SCHEMBL12505624 | 0.82 | TACR3 (0.67) | TACR3 | |
| SCHEMBL7688199 | 0.82 | TACR3 (0.80) | TACR3 | |
| SCHEMBL10026141 | 0.81 | TACR3 (1.00) | TACR3 | |
| SCHEMBL326693 | 0.81 | TACR3 (1.00) | TACR3 | |
| SCHEMBL327493 | 0.81 | TACR3 (0.76) | TACR3 | |
| SCHEMBL6836993 | 0.81 | TACR3 (0.76) | TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590963-B1 | (3-METHYLPYRROLIDIN-3-YL)METHYL PYRIDINYL ETHER DERIVATIVES AND THEIR USE AS NK-3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2014-12-03 | — | — | EP | claimed |
| US-8507535-B2 | Methyl-pyrrolidine ether derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-08-13 | — | — | US | claimed |
| US-20120010212-A1 | METHYL-PYRROLIDINE ETHER DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2012-01-12 | — | — | US | claimed |
| US-8507535-B2 | Methyl-pyrrolidine ether derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20120010212-A1 | METHYL-PYRROLIDINE ETHER DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010212-A1 | METHYL-PYRROLIDINE ETHER DERIVATIVES | OPRM1, OPRK1, OPRD1 | TACR3 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.