SCHEMBL3266255

SCHEMBL3266255

CNC(=O)COC(=O)NCCC1CCN(c2cc3cc(Cl)ccc3cn2)CC1

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.44
CHRM4 P08173 9/20 0.39
SUV39H2 Q9H5I1 2/20 0.38
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
SCD O00767 1/20 0.37
DEGS1 O15121 1/20 0.37
ENPP2 Q13822 1/20 0.36
SMO Q99835 1/20 0.36
MAPK8 P45983 1/20 0.36
CHRM2 P08172 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL239096 0.89 CHRM4 (0.45) FAAHCHRM4
SCHEMBL3270570 0.89 CHRM4 (0.46) CHRM4SUV39H2
SCHEMBL3268724 0.87 FAAH (0.45) FAAHCHRM4SUV39H2SCD
SCHEMBL3268730 0.86 FAAH (0.46) FAAHCHRM4SUV39H2SCD
SCHEMBL3270574 0.85 CHRM4 (0.44) FAAHCHRM4CHRM2CHRM1CHRM3
SCHEMBL3265652 0.84 FAAH (0.48) FAAHCHRM4MAOAMAOBDEGS1
SCHEMBL1730076 0.83 CHRM4 (0.46) CHRM4MAOAMAOBSCDCHRM2
SCHEMBL3266170 0.82 SIRT2 (0.45) FAAHCHRM4SUV39H2MAOAMAOB
SCHEMBL3266982 0.82 SIRT2 (0.45) FAAHCHRM4MAOAMAOBENPP2
SCHEMBL3267181 0.78 CKS1B (0.44) CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120004207-A1 THERAPEUTIC USES OF DERIVATIVES OF PIPERIDINYL-AND PIPERIDINYL-ALKYL CARBAMATES SANOFI-AVENTIS (FR) 2012-01-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120004207-A1 THERAPEUTIC USES OF DERIVATIVES OF PIPERIDINYL-AND PIPERIDINYL-ALKYL CARBAMATES CLCN2, CLIC1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 FAAH 361/4885CHRM4 243/4885SUV39H2 2105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.