Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | MMP14 | P50281 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728573 | 0.78 | APLNR (0.50) | APLNRKCNH2DPP9FPR2SCN9A | |
| SCHEMBL12463409 | 0.72 | JAK2 (0.33) | APLNRADAMTS4MMP13MMP14KCNH2 | |
| SCHEMBL18428183 | 0.72 | JAK2 (0.33) | APLNRADAMTS4MMP13MMP14KCNH2 | |
| SCHEMBL20200794 | 0.72 | ADAMTS4 (0.32) | ADAMTS4MMP13MMP14KCNH2CYP3A4 | |
| SCHEMBL20188375 | 0.71 | APLNR (0.40) | APLNRADAMTS4MMP13MMP14KCNH2 | |
| SCHEMBL20188351 | 0.71 | APLNR (0.40) | APLNRADAMTS4MMP13MMP14KCNH2 | |
| SCHEMBL20190107 | 0.71 | APLNR (0.40) | APLNRADAMTS4MMP13MMP14KCNH2 | |
| SCHEMBL14060678 | 0.71 | APLNR (0.33) | APLNRAGBL2ACACB | |
| SCHEMBL1396189 | 0.71 | AKR1C3 (0.35) | APLNRAGBL2MMP13GAA | |
| SCHEMBL29690056 | 0.71 | FFAR2 (0.35) | APLNRAGBL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020810-A1 | 2-(IMIDAZ0LYLAMIN0)-PYRIDINE DERIVATIVES AND THEIR USE AS JAK KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-02-25 | — | — | WO | disclosed |