Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3266735 | 0.81 | KMT2A (0.41) | KMT2AMTORCYP3A4CYP2D6TSHR | |
| SCHEMBL31688764 | 0.76 | MME (0.50) | KMT2AALDH1A1CHRM2ADRA1ARGS12 | |
| SCHEMBL27555772 | 0.76 | MME (0.50) | KMT2AALDH1A1CHRM2ADRA1ARGS12 | |
| SCHEMBL27555773 | 0.76 | MME (0.50) | KMT2AALDH1A1CHRM2ADRA1ARGS12 | |
| SCHEMBL31369902 | 0.76 | MME (0.50) | KMT2AALDH1A1CHRM2ADRA1ARGS12 | |
| SCHEMBL31370476 | 0.76 | MME (0.50) | KMT2AALDH1A1CHRM2ADRA1ARGS12 | |
| SCHEMBL3266526 | 0.75 | MME (0.44) | KMT2AALDH1A1MTORCHRM2ADRA1A | |
| SCHEMBL7368324 | 0.73 | ALOX5 (0.44) | KMT2AALDH1A1HTTCHRM2ADRA1A | |
| SCHEMBL3272719 | 0.71 | MMP8 (0.45) | ALDH1A1GLACYP2C9CYP2C19HSD17B10 | |
| SCHEMBL22511875 | 0.66 | KMT2A (0.58) | KMT2AALDH1A1HTTCHRM2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506969-B1 | Compounds with growth hormone releasing properties | HELSINN THERAPEUTICS US INC (US) | 2010-06-09 | — | — | EP | disclosed |
| EP-1506969-A1 | Compounds with growth hormone releasing properties | NOVO NORDISK A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| EP-1047709-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2004-11-03 | — | — | EP | disclosed |
| EP-1047709-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 2000-11-02 | — | — | EP | disclosed |
| US-6083908-A | TREATING MEDICAL DISORDERS RESULTING FROM DEFICIENCY IN GROWTH HORMONE | NOVO NORDISK A/S (DK) | 2000-07-04 | — | — | US | disclosed |
| WO-1999036431-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1999-07-22 | — | — | WO | disclosed |