Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | PRCP | P42785 | 4/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | TARS1 | P26639 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3266529 | 0.81 | KMT2A (0.40) | KMT2AALOX5MTORCYP3A4CYP2D6 | |
| SCHEMBL6166986 | 0.80 | KMT2A (0.58) | KMT2ADPP4PRCPCYP3A4CYP1A2 | |
| SCHEMBL20543782 | 0.74 | MMP8 (0.51) | KMT2ADPP4GAATSHR | |
| SCHEMBL3266731 | 0.74 | ALOX5 (0.49) | DPP4ALOX5AOC3GAACYP2D6 | |
| SCHEMBL31263046 | 0.74 | DPP4 (0.47) | DPP4ALOX5AOC3DPP7GAA | |
| SCHEMBL24156377 | 0.73 | DPP4 (0.51) | DPP4ALOX5CYP2D6MAPK1 | |
| SCHEMBL8882516 | 0.73 | DPP4 (0.51) | DPP4ALOX5CYP2D6MAPK1 | |
| SCHEMBL383452 | 0.73 | DPP4 (0.51) | DPP4ALOX5CYP2D6MAPK1 | |
| SCHEMBL383451 | 0.73 | DPP4 (0.51) | DPP4ALOX5CYP2D6MAPK1 | |
| SCHEMBL180086 | 0.73 | DPP4 (0.51) | DPP4ALOX5CYP2D6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506969-B1 | Compounds with growth hormone releasing properties | HELSINN THERAPEUTICS US INC (US) | 2010-06-09 | — | — | EP | disclosed |
| EP-1506969-A1 | Compounds with growth hormone releasing properties | NOVO NORDISK A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| EP-1047709-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2004-11-03 | — | — | EP | disclosed |
| WO-1999036431-A9 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2000-07-27 | — | — | WO | disclosed |
| US-6083908-A | TREATING MEDICAL DISORDERS RESULTING FROM DEFICIENCY IN GROWTH HORMONE | NOVO NORDISK A/S (DK) | 2000-07-04 | — | — | US | disclosed |