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Sugi Predict / Compounds / SCHEMBL3266633

SCHEMBL3266633

SCHEMBL3266633

CN(C(=O)C=CCC1(NC(=O)OC(C)(C)C)CCC1)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N(C)N(C)C

nearest known ligand 0.54

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ GHSR Q92847 8/20 0.50
▸ PPIA P62937 2/20 0.40
▸ CTSB P07858 1/20 0.39
▸ CTSS P25774 1/20 0.39
▸ CTSK P43235 1/20 0.39
▸ TACR1 P25103 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3266625 1.00 GHSR (0.50) GHSRPPIACTSBCTSSCTSK
SCHEMBL1401126 0.85 GHSR (0.42) GHSRPPIATACR1
SCHEMBL1401123 0.85 GHSR (0.42) GHSRPPIATACR1
SCHEMBL1401128 0.85 GHSR (0.42) GHSRPPIATACR1
SCHEMBL3267246 0.84 GHSR (0.50) GHSRTACR1
SCHEMBL3267249 0.84 GHSR (0.50) GHSRTACR1
SCHEMBL14433216 0.80 GHSR (0.66) GHSRTACR1
SCHEMBL867539 0.79 GHSR (0.64) GHSR
SCHEMBL29958716 0.79 GHSR (0.64) GHSR
SCHEMBL867540 0.79 GHSR (0.64) GHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506969-B1 Compounds with growth hormone releasing properties HELSINN THERAPEUTICS US INC (US) 2010-06-09 — — EP disclosed
EP-1506969-A1 Compounds with growth hormone releasing properties NOVO NORDISK A/S (DK) 2005-02-16 — — EP disclosed
EP-1047709-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-11-03 — — EP disclosed