Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 10/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11309832 | 0.81 | POLQ (0.50) | POLQGAATACR1ESR1HDAC6 | |
| SCHEMBL13041529 | 0.81 | POLQ (0.50) | POLQALDH1A1GAATACR1ESR1 | |
| SCHEMBL3399062 | 0.79 | POLQ (0.48) | POLQALDH1A1TACR1ESR1HDAC6 | |
| SCHEMBL13041505 | 0.78 | POLQ (0.47) | POLQALDH1A1GAATACR1ESR1 | |
| SCHEMBL25076165 | 0.76 | TSPO (0.47) | POLQSMN1; SMN2GAATACR1ESR1 | |
| SCHEMBL2088432 | 0.76 | POLQ (0.50) | POLQALDH1A1GAATACR1ESR1 | |
| SCHEMBL2088431 | 0.76 | POLQ (0.46) | POLQSMN1; SMN2ALDH1A1GAATACR1 | |
| SCHEMBL24865037 | 0.75 | SIGMAR1 (0.54) | ALDH1A1HTT | |
| SCHEMBL4602848 | 0.74 | POLQ (0.45) | POLQSMN1; SMN2ALDH1A1GAATACR1 | |
| SCHEMBL5476758 | 0.74 | POLQ (0.45) | POLQSMN1; SMN2ALDH1A1GAATACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740171-B1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-06-09 | — | — | EP | disclosed |