SCHEMBL32669573

SCHEMBL32669573

COc1cc(/C(O)=C(\C#N)C(=O)N(C)Cc2cc(C)ccc2F)cc(C#N)c1O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
ALDH1A1 P00352 1/20 0.36
POLB P06746 1/20 0.36
MAPT P10636 1/20 0.36
GALK1 P51570 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
COMT P21964 1/20 0.34
FTO Q9C0B1 1/20 0.34
CFTR P13569 1/20 0.32
PTGS2 P35354 1/20 0.32
EGFR P00533 3/20 0.31
ERBB2 P04626 2/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
RIPK1 Q13546 1/20 0.31
S1PR1 P21453 1/20 0.31
S1PR3 Q99500 1/20 0.31
AR P10275 3/20 0.31
IMPDH2 P12268 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32669970 0.92 MEN1 (0.39) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL32669816 0.91 S1PR3 (0.38) MEN1KMT2AMAPTCOMTFTO
SCHEMBL32669743 0.91 MEN1 (0.39) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL32670033 0.90 COMT (0.41) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL32669922 0.89 MEN1 (0.38) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL32670105 0.87 ALDH1A1 (0.37) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL32669890 0.86 FTO (0.50) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL32670129 0.84 MEN1 (0.40) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL32669600 0.82 ALDH1A1 (0.39) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL32669805 0.81 S1PR3 (0.42) MEN1KMT2AALDH1A1COMTFTO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 MEN1 3974/4885KMT2A 567/4885ALDH1A1 1334/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.