SCHEMBL32669769

SCHEMBL32669769

Cc1cc(C)c(F)c(CN(C)C(=O)/C(C#N)=C(\O)c2ccc(O)c(C#N)c2)c1

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 1/20 0.35
GCGR P47871 2/20 0.34
COMT P21964 1/20 0.32
FTO Q9C0B1 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.32
GALK1 P51570 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
XDH P47989 1/20 0.31
F11 P03951 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32670129 0.88 MEN1 (0.40) SLC22A12GCGRCOMTFTOMEN1
SCHEMBL32670060 0.79 COMT (0.43) SLC22A12GCGRCOMTFTOALDH1A1
SCHEMBL32670033 0.78 COMT (0.41) COMTFTOMEN1ALDH1A1POLB
SCHEMBL32669970 0.78 MEN1 (0.39) COMTFTOMEN1ALDH1A1POLB
SCHEMBL32669819 0.78 FTO (0.60) COMTFTOMEN1ALDH1A1MAPT
SCHEMBL32669922 0.78 MEN1 (0.38) COMTFTOMEN1ALDH1A1POLB
SCHEMBL32669743 0.77 MEN1 (0.39) COMTFTOMEN1ALDH1A1POLB
SCHEMBL32669777 0.76 SLC22A12 (0.43) SLC22A12GCGRCOMTFTOMEN1
SCHEMBL32670105 0.74 ALDH1A1 (0.37) SLC22A12COMTFTOMEN1ALDH1A1
SCHEMBL32669956 0.73 COMT (0.55) SLC22A12GCGRCOMTFTOMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 SLC22A12 1753/4885GCGR 77/4885COMT 52/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.