SCHEMBL32669781

SCHEMBL32669781

Cc1ccc(F)c(ON(C)C(=O)/C(C#N)=C(\O)c2cc(Cl)c(O)c(C#N)c2)c1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
MEN1 O00255 1/20 0.37
POLB P06746 1/20 0.37
MAPT P10636 1/20 0.37
GALK1 P51570 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
SLC22A12 Q96S37 1/20 0.33
COMT P21964 1/20 0.33
FTO Q9C0B1 1/20 0.33
MRGPRX4 Q96LA9 1/20 0.31
SCN9A Q15858 2/20 0.31
S1PR3 Q99500 2/20 0.30
KDM4E B2RXH2 1/20 0.30
GAA P10253 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32669811 0.85 FTO (0.49) ALDH1A1MEN1POLBMAPTGALK1
SCHEMBL32670105 0.83 ALDH1A1 (0.37) ALDH1A1MEN1POLBMAPTGALK1
SCHEMBL32669967 0.79 FTO (0.52) ALDH1A1MEN1POLBMAPTGALK1
SCHEMBL32669747 0.79 FTO (0.59) ALDH1A1MEN1MAPTKMT2ACOMT
SCHEMBL32669791 0.78 FTO (0.40) SLC22A12COMTFTOS1PR3
SCHEMBL32669875 0.78 FTO (0.51) ALDH1A1MEN1POLBMAPTGALK1
SCHEMBL32669970 0.75 MEN1 (0.39) ALDH1A1MEN1POLBMAPTGALK1
SCHEMBL32669600 0.75 ALDH1A1 (0.39) ALDH1A1MEN1POLBMAPTGALK1
SCHEMBL32669966 0.73 COMT (0.56) ALDH1A1MEN1POLBMAPTKMT2A
SCHEMBL32669799 0.72 FTO (0.43) ALDH1A1MEN1POLBMAPTGALK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 ALDH1A1 1334/4885MEN1 3974/4885POLB 3968/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.