SCHEMBL32670010

SCHEMBL32670010

COc1cc(/C(O)=C(\C#N)C(=O)N(C)CCOc2cccc(NC(C)=O)c2)cc([N+](=O)[O-])c1O

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.44
MEN1 O00255 4/20 0.44
FTO Q9C0B1 2/20 0.43
COMT P21964 1/20 0.43
MAPT P10636 2/20 0.39
HTT P42858 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
JAK2 O60674 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
EGFR P00533 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32669579 0.89 FTO (0.49) KMT2AMEN1FTOCOMTMAPT
SCHEMBL32670122 0.88 FTO (0.45) KMT2AMEN1FTOCOMTEGFR
SCHEMBL32669627 0.85 FTO (0.43) KMT2AMEN1FTOCOMTMAPT
SCHEMBL32669918 0.84 FTO (0.42) KMT2AMEN1FTOCOMTEGFR
SCHEMBL32670057 0.84 KMT2A (0.47) KMT2AMEN1FTOCOMTMAPT
SCHEMBL32669870 0.84 FTO (0.53) KMT2AMEN1FTOCOMTMAPT
SCHEMBL32669871 0.84 FTO (0.51) KMT2AMEN1FTOCOMTMAPT
SCHEMBL32669778 0.83 FTO (0.47) KMT2AMEN1FTOCOMTMAPT
SCHEMBL32670048 0.82 SMN1; SMN2 (0.41) KMT2AMEN1MAPTSMN1; SMN2
SCHEMBL32669671 0.82 FTO (0.46) KMT2AMEN1FTOCOMTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 KMT2A 567/4885MEN1 3974/4885FTO 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.