SCHEMBL32670048

SCHEMBL32670048

CC(=O)Nc1cccc(OCCN(C)C(=O)/C(C#N)=C(\O)c2cc(Cl)c(O)c(Cl)c2)c1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
HTR1A P08908 2/20 0.41
MAPT P10636 2/20 0.41
KDM1A O60341 1/20 0.41
MAOB P27338 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
DRD2 P14416 1/20 0.40
HTR2A P28223 1/20 0.40
ALDH1A1 P00352 1/20 0.38
KDM4E B2RXH2 1/20 0.38
HSD17B10 Q99714 1/20 0.38
AHR P35869 1/20 0.38
NR1H4 Q96RI1 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32670010 0.82 KMT2A (0.44) SMN1; SMN2MAPTMEN1KMT2A
SCHEMBL32669822 0.82 LTB4R (0.41) ALDH1A1KDM4E
SCHEMBL32670068 0.82 KDM4E (0.37) SMN1; SMN2MEN1KMT2AALDH1A1KDM4E
SCHEMBL32669930 0.81 RAB9A (0.38) SMN1; SMN2RAB9AMAPTMEN1KMT2A
SCHEMBL32669759 0.79 PORCN (0.36) NPC1RAB9AKMT2AKDM4E
SCHEMBL32669969 0.78 FTO (0.50) SMN1; SMN2MAPTMEN1KMT2AALDH1A1
SCHEMBL32669571 0.77 SLC22A12 (0.36) NPC1RAB9AMEN1KMT2AKDM4E
SCHEMBL32669598 0.76 COMT (0.32) ALDH1A1KDM4E
SCHEMBL32669964 0.75 ALDH1A1 (0.41) MEN1KMT2AALDH1A1
SCHEMBL32669810 0.75 EGFR (0.34) HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 SMN1; SMN2 2140/4885NPC1 40/4885RAB9A 3162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.