Detirelix Acetate

Detirelix Acetate

SCHEMBL32670260

CCNC(=NCCCC[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O)NCC

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GNRHR P30968 7/20 0.74
DRD1 P21728 1/20 0.67
OPRM1 P35372 1/20 0.67
MRGPRX2 Q96LB1 1/20 0.67
ABCB11 O95342 1/20 0.66
ABCC2 Q92887 1/20 0.56
KISS1R Q969F8 2/20 0.54
NMUR2 Q9GZQ4 1/20 0.54
NMUR1 Q9HB89 1/20 0.54
CXCL8 P10145 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Detirelix Acetate SCHEMBL722712 1.00 GNRHR (0.74) GNRHRDRD1OPRM1MRGPRX2ABCB11
Detirelix Acetate SCHEMBL29406059 0.96 GNRHR (0.68) GNRHRDRD1OPRM1MRGPRX2ABCB11
Detirelix Acetate SCHEMBL422026 0.96 GNRHR (0.68) GNRHRDRD1OPRM1MRGPRX2ABCB11
Detirelix Acetate SCHEMBL29893517 0.96 GNRHR (0.68) GNRHRDRD1OPRM1MRGPRX2ABCB11
Detirelix Acetate SCHEMBL635713 0.95 GNRHR (0.70) GNRHRDRD1OPRM1MRGPRX2ABCB11
Acetic Acid SCHEMBL719624 0.92 GNRHR (0.64) GNRHRDRD1OPRM1MRGPRX2ABCB11
Cetrorelix SCHEMBL21174252 0.89 GNRHR (0.84) GNRHRDRD1OPRM1MRGPRX2ABCB11
SCHEMBL11099432 0.89 KISS1R (0.63) GNRHRDRD1OPRM1MRGPRX2ABCB11
SCHEMBL11207519 0.88 GNRHR (0.61) GNRHRDRD1OPRM1MRGPRX2ABCB11
SCHEMBL11200262 0.87 GNRHR (0.59) GNRHRDRD1OPRM1MRGPRX2ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260034192-A1 USE OF GNRH ANTAGONISTS IN MAMMALS TO SYNCHRONIZE FOLLICULAR WAVE EMERGENCE UNIV SASKATCHEWAN (CA) 2026-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260034192-A1 USE OF GNRH ANTAGONISTS IN MAMMALS TO SYNCHRONIZE FOLLICULAR WAVE EMERGENCE GNRHR, FSHR, PGF GNRHR 1/4885DRD1 1711/4885OPRM1 94/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.