Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3267871 | 1.00 | NPC1 (0.44) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL1010516 | 0.91 | TSHR (0.48) | NPC1RAB9AHPGDMAPTKDM4E | |
| SCHEMBL27165412 | 0.89 | RAB9A (0.47) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8512454 | 0.88 | KMT2A (0.49) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL8512457 | 0.88 | KMT2A (0.49) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL9899633 | 0.86 | SMN1; SMN2 (0.47) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL9899631 | 0.86 | SMN1; SMN2 (0.47) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL27165420 | 0.86 | HDAC8 (0.45) | SMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL6555908 | 0.85 | CES2 (0.56) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6555910 | 0.85 | CES2 (0.56) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963896-B1 | PHOTOCHROMIC MATERIALS HAVING ELECTRON-WITHDRAWING SUBSTITUENTS | TRANSITIONS OPTICAL INC (US) | 2010-02-10 | — | — | EP | disclosed |
| US-7556751-B2 | Photochromic materials having electron-withdrawing substituents | TRANSITIONS OPTICAL, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-20070138449-A1 | Photochromic materials having electron-withdrawing substituents | TRANSITIONS OPTICAL LIMITED (IE) | 2007-06-21 | — | — | US | disclosed |