Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ESRRB | O95718 | 2/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9899633 | 0.92 | SMN1; SMN2 (0.47) | HPGDMAPTMAPK1SMN1; SMN2HDAC3 | |
| SCHEMBL9899631 | 0.92 | SMN1; SMN2 (0.47) | HPGDMAPTMAPK1SMN1; SMN2HDAC3 | |
| SCHEMBL3267872 | 0.91 | NPC1 (0.44) | TSHRESRRBKMT2AHPGDMEN1 | |
| SCHEMBL6555910 | 0.91 | CES2 (0.56) | KMT2ACES1KDM4ESMN1; SMN2CA1 | |
| SCHEMBL6555908 | 0.91 | CES2 (0.56) | KMT2ACES1KDM4ESMN1; SMN2CA1 | |
| SCHEMBL3267871 | 0.91 | NPC1 (0.44) | TSHRESRRBKMT2AHPGDMEN1 | |
| SCHEMBL1331949 | 0.87 | CA12 (0.51) | TSHRKMT2AHPGDMEN1KDM4E | |
| SCHEMBL1331951 | 0.87 | CA12 (0.51) | TSHRKMT2AHPGDMEN1KDM4E | |
| SCHEMBL3264549 | 0.86 | ALDH1A1 (0.50) | KMT2AMEN1CES1KDM4EMAPT | |
| SCHEMBL24620799 | 0.84 | ALDH1A1 (0.53) | TSHRKMT2AMEN1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898590-B1 | METHOD FOR PREPARING INDOLENAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-22 | — | — | EP | disclosed |
| EP-3898636-B9 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-08 | — | — | EP | disclosed |
| EP-3898636-B1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-08-30 | — | — | EP | disclosed |
| US-20220073533-A1 | Method for Preparing Indolenaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-03-10 | — | — | US | disclosed |
| US-20220056039-A1 | Indolonaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-02-24 | — | — | US | disclosed |
| WO-2020126032-A1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020126033-A1 | METHOD FOR PREPARING INDOLENAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
| US-9643905-B2 | Phenylnaphthol derivatives | TOKUYAMA CORPORATION (JP) | 2017-05-09 | — | — | US | disclosed |
| US-9643905-B2 | Phenylnaphthol derivatives | TOKUYAMA CORPORATION (JP) | 2017-05-09 | — | — | US | disclosed |
| US-20160130203-A1 | NOVEL PHENYLNAPHTHOL DERIVATIVES | TOKUYAMA CORPORATION (JP) | 2016-05-12 | — | — | US | disclosed |
| US-5955520-A | 1H-INDENO(2,1-F)NAPHTHO(1,2-B)PYRANS HAVING ACTIVATED COLORS RANGING FROM ORANGE TO BLUE/GRAY, AN ACCEPTABLE FADE RATE, HIGH ACTIVATED COLORS RANGING FROM ORGANE TO BLUE/GRAY, AN ACCEPTABLE FAD RATE, HIGH ACTIVATED INTENSITY | PPG INDUSTRIES, INC. (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0906366-A1 | NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| EP-0792468-A4 | NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | PPG INDUSTRIES INC (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0835870-A1 | Photochromic substituted naphthopyrans | PPG INDUSTRIES, INC. (US) | 1998-04-15 | — | — | EP | disclosed |
| WO-1998014443-A1 | NOVEL SUBSTITUTED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1998-04-09 | — | — | WO | disclosed |
| WO-1997048762-A1 | NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1997-12-24 | — | — | WO | disclosed |
| EP-0792468-A1 | NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1997-09-03 | — | — | EP | disclosed |
| US-5656206-A | OPHTHALIMIC LENSES; RADIATION TRANSPARENT; PHOTOCHROMISM | TRANSITIONS OPTICAL, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5645767-A | PLASTIC LENSES, WINDOWS, BATHOCHROMIC SHIFT FOR WAVELENGTHS IN VISIBLE SPECTRUM | TRANSITIONS OPTICAL, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1996014596-A1 | NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1996-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130203-A1 | NOVEL PHENYLNAPHTHOL DERIVATIVES | AHR, ARL1, PAH | TSHR 2179/4885ESRRB 2720/4885NR4A2 187/4885 |
| US-20220056039-A1 | Indolonaphthopyrans | TPH1, TPH2, IDO1 | TSHR 514/4885ESRRB 1134/4885NR4A2 1718/4885 |
| US-20220073533-A1 | Method for Preparing Indolenaphthopyrans | CCNH, CCNT1, PAH | TSHR 1331/4885ESRRB 3983/4885NR4A2 3169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.