Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 15/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.56 |
| ▸ | ABCC1 | P33527 | 5/20 | 0.56 |
| ▸ | WHR1 | P49842 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ACACA | Q13085 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25082162 | 0.84 | ABCG2 (0.58) | ABCG2ABCB1ABCC1WHR1TP53 | |
| SCHEMBL8816999 | 0.83 | ABCG2 (0.47) | ABCG2L3MBTL1ABCB1ABCC1WHR1 | |
| SCHEMBL6001414 | 0.82 | ABCG2 (0.58) | ABCG2L3MBTL1ABCB1ABCC1WHR1 | |
| SCHEMBL8818335 | 0.79 | L3MBTL1 (0.53) | ABCG2L3MBTL1ABCB1ABCC1WHR1 | |
| SCHEMBL28054620 | 0.78 | ABCG2 (0.65) | ABCG2L3MBTL1ABCB1ABCC1TP53 | |
| SCHEMBL8779739 | 0.78 | ABCG2 (0.49) | ABCG2L3MBTL1ABCB1ABCC1TP53 | |
| SCHEMBL8779566 | 0.77 | ABCG2 (0.48) | ABCG2L3MBTL1ABCB1ABCC1TP53 | |
| SCHEMBL3786521 | 0.76 | ABCG2 (0.47) | ABCG2L3MBTL1ABCB1ABCC1TP53 | |
| SCHEMBL182874 | 0.76 | PDGFRB (0.48) | L3MBTL1SMN1; SMN2 | |
| SCHEMBL27767946 | 0.75 | L3MBTL1 (0.58) | ABCG2L3MBTL1ABCB1ABCC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |