Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 2/20 | 0.38 |
| ▸ | SELE | P16581 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.32 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.32 |
| ▸ | TUBB | P07437 | 2/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3268815 | 0.88 | TNKS2 (0.38) | MAPK8MEN1KMT2APARP15TNKS2 | |
| SCHEMBL3275192 | 0.87 | EDNRA (0.46) | MAPK8MEN1KMT2APARP15TNKS2 | |
| SCHEMBL3269919 | 0.87 | PDE4B (0.38) | MAPK8MEN1KMT2APARP15TNKS2 | |
| SCHEMBL3270312 | 0.86 | TNKS2 (0.39) | MEN1KMT2APARP15TNKS2PARP10 | |
| SCHEMBL3177241 | 0.83 | ICAM1 (0.42) | ICAM1SELEMAPK8KDRPARP15 | |
| SCHEMBL3268577 | 0.82 | KDR (0.39) | ICAM1SELEMAPK8KDRPARP1 | |
| SCHEMBL3269142 | 0.81 | PARP15 (0.33) | PARP15TNKS2PARP10PARP2PARP14 | |
| SCHEMBL3268792 | 0.79 | CDC7 (0.36) | PARP15TNKS2PARP10PARP2TNKS | |
| SCHEMBL3268877 | 0.78 | PARP15 (0.35) | MEN1KMT2APARP15TNKS2PARP10 | |
| SCHEMBL3270015 | 0.76 | TUBB4A (0.42) | MAPK8PARP15TNKS2PARP10PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784409-B1 | SUBSTITUTED THIENOPYRROLE CARBOXYLIC ACID AMIDES, PYRROLOTHIAZOLE CARBOXYLIC ACID AMIDES, AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2010-06-16 | — | — | EP | claimed |