Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.32 |
| ▸ | TUBB | P07437 | 2/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.32 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.32 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.32 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3268889 | 0.90 | MAPK8 (0.32) | MAPK8MAPTPARP1 | |
| SCHEMBL3275434 | 0.87 | EDNRA (0.43) | KDRALDH1A1MAPK8LMNAHSD17B10 | |
| SCHEMBL3269545 | 0.87 | TYMS (0.35) | KDRMAPK8PARP1 | |
| SCHEMBL3269989 | 0.87 | KDR (0.39) | KDRMAPK8GCKTUBB4ATUBB | |
| SCHEMBL3269983 | 0.86 | ALDH1A1 (0.34) | ICAM1SELEALDH1A1HTTTDP1 | |
| SCHEMBL3268931 | 0.86 | TUBB4A (0.37) | KDRALDH1A1TUBB4ATUBBTUBA3C | |
| SCHEMBL3185243 | 0.83 | KDR (0.41) | KDRICAM1SELEMAPK8GCK | |
| SCHEMBL3268262 | 0.82 | ICAM1 (0.38) | KDRICAM1SELEMAPK8GCK | |
| SCHEMBL3269135 | 0.82 | RHEB (0.43) | MAPK8TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3269102 | 0.81 | PDPK1 (0.36) | LMNATUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784409-B1 | SUBSTITUTED THIENOPYRROLE CARBOXYLIC ACID AMIDES, PYRROLOTHIAZOLE CARBOXYLIC ACID AMIDES, AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2010-06-16 | — | — | EP | claimed |