Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | NEK4 | P51957 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 9/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3270312 | 0.88 | TNKS2 (0.39) | PARP15TNKS2TNKSPARP1PARP10 | |
| SCHEMBL3269142 | 0.82 | PARP15 (0.33) | TYMSDHFRPARP15TNKS2TNKS | |
| SCHEMBL3268877 | 0.81 | PARP15 (0.35) | PARP15TNKS2TNKSPARP1PARP10 | |
| SCHEMBL3167801 | 0.81 | PTGS2 (0.39) | CDC7MAPK13DAPK3ROCK2MAP4K4 | |
| SCHEMBL3268326 | 0.81 | CCNC (0.33) | CDC7TYMSDHFRDDAH1NOS1 | |
| SCHEMBL3272415 | 0.80 | ICAM1 (0.36) | PARP15TNKS2TNKSPARP1PARP2 | |
| SCHEMBL3268815 | 0.80 | TNKS2 (0.38) | TYMSPARP15TNKS2TNKSPARP1 | |
| SCHEMBL3269919 | 0.79 | PDE4B (0.38) | TYMSDHFRPARP15TNKS2TNKS | |
| SCHEMBL3268262 | 0.79 | ICAM1 (0.38) | PARP15TNKS2TNKSPARP1PARP10 | |
| SCHEMBL3275192 | 0.78 | EDNRA (0.46) | CSNK2A1PARP15TNKS2PARP1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784409-B1 | SUBSTITUTED THIENOPYRROLE CARBOXYLIC ACID AMIDES, PYRROLOTHIAZOLE CARBOXYLIC ACID AMIDES, AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2010-06-16 | — | — | EP | claimed |