Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2996053 | 0.82 | ALDH1A1 (0.69) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL10376255 | 0.82 | MEN1 (0.80) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL3005825 | 0.81 | HPGD (0.78) | ALDH1A1HPGDHTTNPSR1LMNA | |
| SCHEMBL2999401 | 0.81 | ALDH1A1 (0.69) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL3003790 | 0.79 | ALDH1A1 (0.66) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL4263306 | 0.78 | ALDH1A1 (0.77) | ALDH1A1HPGDHTTKMT2ANPSR1 | |
| SCHEMBL10377483 | 0.78 | ADORA3 (0.80) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL2996052 | 0.78 | ALDH1A1 (0.63) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL3248337 | 0.77 | ALDH1A1 (0.75) | ALDH1A1HPGDHTTKMT2ANPSR1 | |
| SCHEMBL3000256 | 0.77 | ALDH1A1 (0.62) | ALDH1A1HPGDHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |