Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 17/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3267361 | 0.81 | NOTUM (0.53) | NOTUMKDM4EALDH1A1HPGDCYP11B1 | |
| SCHEMBL27497129 | 0.79 | NOTUM (0.50) | NOTUMKDM4EALDH1A1HPGDCYP11B1 | |
| SCHEMBL5881634 | 0.77 | NOTUM (0.48) | NOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL1761252 | 0.77 | NOTUM (0.48) | NOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL5881552 | 0.76 | NOTUM (0.47) | NOTUMKDM4EALDH1A1HPGDCYP11B1 | |
| SCHEMBL1761149 | 0.76 | NOTUM (0.61) | NOTUMKDM4EALDH1A1HPGDCYP11B1 | |
| SCHEMBL5881609 | 0.74 | NOTUM (0.45) | NOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL6644014 | 0.73 | EIF2AK3 (0.47) | KDM4EALDH1A1 | |
| SCHEMBL5881721 | 0.73 | NOTUM (0.44) | NOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL3269518 | 0.71 | NOTUM (0.41) | NOTUMCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1541553-B1 | INDOLINE COMPOUND AND MEDICINAL USE THEREOF | KYOTO PHARMA IND (JP) | 2010-06-02 | — | — | EP | disclosed |
| US-7429612-B2 | Indoline compound and medicinal use thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2008-09-30 | — | — | US | disclosed |
| CN-100349868-C | Indoline compound and medical use thereof | KYOTO PHARMA IND (JP) | 2007-11-21 | — | — | CN | disclosed |
| US-20060128787-A1 | Novel indoline compound and medicinal use thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2006-06-15 | — | — | US | disclosed |
| CN-1681781-A | Novel indoline compound and medicinal use thereof | KYOTO PHARMA IND (JP) | 2005-10-12 | — | — | CN | disclosed |
| EP-1541553-A1 | NOVEL INDOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-20040157866-A1 | Amide compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128787-A1 | Novel indoline compound and medicinal use thereof | ACAT2, ACAT1, ACOX1 | NOTUM 219/4885KDM4E 1777/4885ALDH1A1 94/4885 |
| US-20040157866-A1 | Amide compounds | APOB, NR1H2, NR1H3 | NOTUM 804/4885KDM4E 2600/4885ALDH1A1 2901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.