Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | DDX3X | O00571 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278196 | 0.95 | KMT2A (0.47) | KMT2AALDH1A1HTTGAAMAPT | |
| Trifluoroacetic Acid SCHEMBL3270278 | 0.92 | MTNR1B (0.45) | MAPTKDREPHX2HDAC3HDAC4 | |
| SCHEMBL3281277 | 0.86 | MTNR1B (0.49) | MAPTROCK2KDREPHX2 | |
| Trifluoroacetic Acid SCHEMBL8216241 | 0.84 | HDAC3 (0.40) | KMT2AALDH1A1HTTMAPTPPARA | |
| Trifluoroacetic Acid SCHEMBL4460353 | 0.84 | MCL1 (0.47) | PPARAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3269527 | 0.83 | ALOX5 (0.50) | KMT2AROCK2PPARAKDREPHX2 | |
| SCHEMBL3269768 | 0.82 | MAPT (0.38) | ALDH1A1HTTMAPTHDAC3HDAC4 | |
| SCHEMBL3275815 | 0.81 | GBA1 (0.46) | KMT2AALDH1A1KDREPHX2CDK8 | |
| SCHEMBL4457369 | 0.80 | MEN1 (0.48) | KMT2AALDH1A1HTTMAPTNPSR1 | |
| SCHEMBL3270529 | 0.80 | MAPK1 (0.47) | ALDH1A1HTTROCK2PPARAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024335-B1 | NOVEL IMIDAZOLE DERIVATIVES, PREPARATION AND USER THEREOF AS MEDICINE | IPSEN PHARMA (FR) | 2010-06-23 | — | — | EP | claimed |
| US-20090186930-A1 | NOVEL IMIDAZOLE DERIVATIVES, PREPARATION AND USER THEREOF AS MEDICINE | SOCIETE DE CONSEILS DE RECHERCHES ET D' APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2009-07-23 | — | — | US | claimed |
| US-8188133-B2 | Imidazole derivatives, preparation and user thereof as medicine | IPSEN PHARMA S.A.S. (FR) | 2012-05-29 | — | — | US | disclosed |
| US-20090186930-A1 | NOVEL IMIDAZOLE DERIVATIVES, PREPARATION AND USER THEREOF AS MEDICINE | SOCIETE DE CONSEILS DE RECHERCHES ET D' APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186930-A1 | NOVEL IMIDAZOLE DERIVATIVES, PREPARATION AND USER THEREOF AS MEDICINE | CYP51A1, IKZF3, MIF | KMT2A 1928/4885ALDH1A1 776/4885HTT 4815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.