SCHEMBL3269816

SCHEMBL3269816

C=CC(=O)OCCC(Cl)Cl.[SiH3]Cl

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.52
ALDH1A1 P00352 4/20 0.52
TP53 P04637 3/20 0.52
HIF1A Q16665 3/20 0.52
CYP3A4 P08684 2/20 0.52
HSD17B10 Q99714 1/20 0.52
HPGD P15428 1/20 0.47
MAPK1 P28482 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
THRB P10828 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10714314 0.96 TSHR (0.56) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL27996715 0.84 TSHR (0.63) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL709412 0.82 TSHR (0.54) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL11805799 0.78 TSHR (0.55) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL3360841 0.77 TSHR (0.48) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL996461 0.77 TSHR (0.58) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL6368712 0.77 TSHR (0.58) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL10337184 0.77 TSHR (0.58) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL13583601 0.76 TSHR (0.52) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL933009 0.76 TSHR (0.48) TSHRALDH1A1TP53HIF1ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593297-B1 Resin composition for coating and paint HITACHI CHEMICAL CO LTD (JP) 1997-04-16 EP claimed
US-5539051-A ACRYLATE RESIN AND ADDITION TYPE RESIN WITH PENDANT SILICON CONTAINING GROUPS, FOR CONCRETE, MASONRY, NONSTAINING HITACHI CHEMICAL COMPANY CO., LTD. (JP) 1996-07-23 US claimed
EP-0593297-A1 Resin composition for coating and paint HITACHI CHEMICAL CO., LTD. (JP) 1994-04-20 EP claimed
EP-1854822-B1 Optical devices made from radiation curable fluorinated compositions ENABLENCE TECHNOLOGIES USA INC (CA) 2010-06-23 EP disclosed
EP-1854822-A1 Optical devices made from radiation curable fluorinated compositions E.I. DU PONT DE NEMOURS AND COMPANY (US) 2007-11-14 EP disclosed
EP-1203031-B1 OPTICAL DEVICES MADE FROM RADIATION CURABLE FLUORINATED COMPOSITIONS DU PONT (US) 2007-10-24 EP disclosed
EP-1845109-A2 Optical devices made from radiation curable fluorinated compositions E.I. Du Pont de Nemours and Company (US) 2007-10-17 EP disclosed
EP-1352009-B1 OPTICAL DEVICES MADE FROM RADIATION CURABLE FLUORINATED COMPOSITIONS DU PONT (US) 2007-08-08 EP disclosed
EP-1203031-A4 OPTICAL DEVICES MADE FROM RADIATION CURABLE FLUORINATED COMPOSITIONS DU PONT (US) 2004-11-24 EP disclosed
US-6800424-B2 ORGANIC OPTICAL WAVEGUIDE DEVICES WHICH EMPLOY PERFLUOROPOLYMERIC MATERIALS HAVING LOW OPTICAL LOSS AND LOW BIREFRINGENCE. AN OPTICAL ELEMENT HAS A SUBSTRATE; A PATTERNED, LIGHT TRANSMISSIVE PERFLUOROPOLYMER CORE E. I. DU PONT DE NEMOURS AND COMPANY 2004-10-05 US disclosed
US-20030207215-A1 Organic optical waveguide devices which employ perfluoropolymeric materials having low optical loss and low birefringence. An optical element has a substrate; a patterned, light transmissive perfluoropolymer core ENABLENCE TECHNOLOGIES USA INC. (CA) 2003-11-06 US disclosed
EP-1352009-A2 OPTICAL DEVICES MADE FROM RADIATION CURABLE FLUORINATED COMPOSITIONS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-10-15 EP disclosed
US-6555288-B1 A light transmissive perfluoropolymer core composition comprising octafluorohexanediol di-acrylate compound and acrylated polyether; photopolymerizable CORNING INCORPORATED 2003-04-29 US disclosed
WO-2002050583-A2 OPTICAL DEVICES MADE FROM RADIATION CURABLE FLUORINATED COMPOSITIONS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2002-06-27 WO disclosed
EP-1203031-A1 OPTICAL DEVICES MADE FROM RADIATION CURABLE FLUORINATED COMPOSITIONS CORNING INCORPORATED (US) 2002-05-08 EP disclosed
US-20020006586-A1 Optical devices made from radiation curable fluorinated compositions CORNING INCORPORATED 2002-01-17 US disclosed
US-6306563-B1 Optical devices made from radiation curable fluorinated compositions CORNING INC. 2001-10-23 US disclosed
WO-2000078819-A1 OPTICAL DEVICES MADE FROM RADIATION CURABLE FLUORINATED COMPOSITIONS CORNING INCORPORATED (US) 2000-12-28 WO disclosed