Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCL5 | P13501 | 18/20 | 0.70 |
| ▸ | CCR5 | P51681 | 11/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278106 | 0.98 | CCL5 (0.73) | CCL5CCR5KCNH2 | |
| SCHEMBL3277013 | 0.91 | CCL5 (0.72) | CCL5CCR5 | |
| SCHEMBL3271746 | 0.90 | CCL5 (0.61) | CCL5CCR5KCNH2 | |
| SCHEMBL3272913 | 0.89 | CCL5 (0.71) | CCL5CCR5 | |
| SCHEMBL3270715 | 0.88 | CCL5 (0.73) | CCL5CCR5KCNH2 | |
| SCHEMBL3274489 | 0.87 | CCL5 (0.58) | CCL5CCR5KCNH2 | |
| SCHEMBL3276064 | 0.87 | CCL5 (0.56) | CCL5CCR5KCNH2 | |
| SCHEMBL3269970 | 0.86 | CCL5 (0.94) | CCL5CCR5KCNH2 | |
| SCHEMBL3273267 | 0.85 | CCL5 (0.72) | CCL5CCR5KCNH2 | |
| SCHEMBL3271198 | 0.85 | CCL5 (0.73) | CCL5CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066674-B1 | OCTAHYDROPYRROLO [3, 4-C] PYRROLE DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | claimed |
| US-7625905-B2 | Octahydro-pyrrolo[3,4-c]pyrrole CCR5 receptor antagonists | ROCHE PALO ALTO LLC (US) | 2009-12-01 | — | — | US | claimed |
| US-20080103125-A1 | Heterocylic antiviral compounds | ROCHE PALO ALTO LLC | 2008-05-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103125-A1 | Heterocylic antiviral compounds | CCR5, ACKR3, CXCR3 | CCL5 11/4885CCR5 1/4885KCNH2 3419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.