SCHEMBL3270795

SCHEMBL3270795

COc1ccc(-c2ccc(C(=CCSc3ccc(O)c(C)c3)c3ccc(Cl)cc3)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 4/20 0.43
ALPG P10696 1/20 0.41
HPGD P15428 2/20 0.37
MAPT P10636 4/20 0.37
THRB P10828 1/20 0.37
LMNA P02545 3/20 0.36
ALOX12 P18054 2/20 0.36
TP53 P04637 1/20 0.36
GAA P10253 1/20 0.36
ALOX15 P16050 1/20 0.36
MAPK1 P28482 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
MAOB P27338 2/20 0.34
MAOA P21397 1/20 0.34
POLB P06746 1/20 0.34
KDM4E B2RXH2 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3280960 0.89 PPARD (0.43) PPARDALPGHPGDMAPTALOX12
SCHEMBL3266067 0.89 PPARD (0.55) PPARDALPGHPGDMAPTLMNA
SCHEMBL3270793 0.88 PPARD (0.44) PPARDALPGHPGDMAPTTHRB
SCHEMBL3270787 0.88 PPARD (0.44) PPARDALPGHPGDMAPTTHRB
SCHEMBL657911 0.83 PPARD (0.67) PPARD
SCHEMBL657910 0.83 PPARD (0.67) PPARD
SCHEMBL3267255 0.81 PPARD (0.51) PPARDALPGMAPTLMNAKMT2A
SCHEMBL3266552 0.78 PPARD (0.50) PPARDALPGALOX15MAOBCYP1A2
SCHEMBL3280957 0.77 PPARD (0.44) PPARDHPGDMAPTALOX12MEN1
SCHEMBL3266065 0.77 PPARD (0.57) PPARDHPGDMAPTLMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1558571-B1 NOVEL COMPOUNDS USEFUL IN TREATING PPAR MEDIATED DISEASES HIGH POINT PHARMACEUTICALS LLC (US) 2010-06-02 EP claimed